{"id":11443,"date":"2026-07-23T18:25:46","date_gmt":"2026-07-23T16:25:46","guid":{"rendered":"https:\/\/www.synlab.fr\/alpigene\/?p=11443"},"modified":"2026-07-24T09:47:10","modified_gmt":"2026-07-24T07:47:10","slug":"dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale","status":"publish","type":"post","link":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/","title":{"rendered":"DPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21"},"content":{"rendered":"
\n\n\t\t\t
\n\t\t\t\t\t\t

Le d\u00e9pistage pr\u00e9natal non invasif (DPNI), bas\u00e9 sur l’analyse de l’ADN libre circulant dans le sang maternel, est aujourd’hui int\u00e9gr\u00e9 \u00e0 la strat\u00e9gie nationale de d\u00e9pistage de la trisomie 21. Fiable et sans risque pour la m\u00e8re et le f\u0153tus, il permet de r\u00e9duire significativement le recours aux examens invasifs tels que l’amniocent\u00e8se ou le pr\u00e9l\u00e8vement de villosit\u00e9s choriales.<\/p>\n

R\u00e9alis\u00e9 \u00e0 partir d’une simple prise de sang, le DPNI analyse des fragments d’ADN d’origine placentaire pr\u00e9sents dans la circulation sanguine maternelle afin de d\u00e9tecter une \u00e9ventuelle surrepr\u00e9sentation du chromosome 21. Cet examen pr\u00e9sente une sensibilit\u00e9 sup\u00e9rieure \u00e0 99 % pour le d\u00e9pistage de la trisomie 21. Il reste toutefois un test de d\u00e9pistage : tout r\u00e9sultat \u00e0 haut risque doit \u00eatre confirm\u00e9 par un examen diagnostique invasif.<\/p>\n<\/article>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\n\t\n\t\t\n<\/div>\n\n\n\n\n\t\n\t\n\n\n\n

\n\n \n \n<\/div>\n\n
\n\n\t\t\t
\n\t\t\t

Dans quels cas le DPNI est-il pris en charge ?<\/h2>\t\t\t

Depuis son int\u00e9gration dans le programme national de d\u00e9pistage, le DPNI est rembours\u00e9 par l’Assurance Maladie lorsqu’il est r\u00e9alis\u00e9 dans le cadre des recommandations en vigueur. Il est notamment propos\u00e9 aux femmes enceintes pr\u00e9sentant un risque de trisomie 21 compris entre 1\/51 et 1\/1000 \u00e0 l’issue du d\u00e9pistage combin\u00e9 du premier trimestre ou du d\u00e9pistage par marqueurs s\u00e9riques du deuxi\u00e8me trimestre.<\/p>\n

La prise en charge peut \u00e9galement concerner certaines situations particuli\u00e8res :<\/p>\n

    \n
  • grossesse g\u00e9mellaire ;<\/li>\n
  • ant\u00e9c\u00e9dent de grossesse avec trisomie 21 ;<\/li>\n
  • impossibilit\u00e9 d’interpr\u00e9ter de mani\u00e8re fiable les marqueurs s\u00e9riques maternels ;<\/li>\n
  • situations sp\u00e9cifiques \u00e9valu\u00e9es dans le cadre des recommandations nationales.<\/li>\n<\/ul>\n

    Lorsque le risque estim\u00e9 est sup\u00e9rieur ou \u00e9gal \u00e0 1\/50, un examen diagnostique invasif est habituellement propos\u00e9 d’embl\u00e9e, m\u00eame si un DPNI peut \u00eatre discut\u00e9 avec la patiente selon le contexte clinique et son choix \u00e9clair\u00e9.<\/p>\n<\/article>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\n\t\n\t\t\n<\/div>\n\n\n\n\n\t\n\t\n\n\n\n

    \n\n \n \n<\/div>\n\n
    \n\n\t\t\t
    \n\t\t\t

    Le r\u00f4le essentiel du prescripteur<\/h2>\t\t\t

    Conform\u00e9ment \u00e0 la r\u00e9glementation, la r\u00e9alisation d’un DPNI n\u00e9cessite une information pr\u00e9alable de la patiente et le recueil de son consentement \u00e9crit. Le prescripteur veille \u00e0 expliquer les performances et les limites de l’examen, ainsi que les \u00e9ventuelles suites \u00e0 donner en fonction du r\u00e9sultat obtenu.<\/p>\n

    Il est \u00e9galement important de rappeler qu’un r\u00e9sultat n\u00e9gatif ne dispense pas du suivi \u00e9chographique de la grossesse. Les \u00e9chographies restent indispensables pour d\u00e9pister d’autres anomalies f\u0153tales et assurer une surveillance optimale de la grossesse.<\/p>\n<\/article>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\n\t\n\t\t\n<\/div>\n\n\n\n\n\t\n\t\n\n\n\n

    \n\n \n \n<\/div>\n\n
    \n\n\t\t\t
    \n\t\t\t\t\t\t

    Alpig\u00e8ne accompagne les professionnels de sant\u00e9 dans la prescription, la r\u00e9alisation et l’interpr\u00e9tation du DPNI, en conformit\u00e9 avec les recommandations de la Haute Autorit\u00e9 de Sant\u00e9 et la r\u00e9glementation fran\u00e7aise en vigueur.<\/p>\n<\/article>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\n\t\n\t\t\n<\/div>\n\n\n\n\n\t\n\t\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    Le d\u00e9pistage pr\u00e9natal non invasif (DPNI), , constitue aujourd’hui un examen majeur de d\u00e9pistage de la trisomie 21. Son excellente performance diagnostique permet de r\u00e9duire significativement le recours aux examens invasifs tels que l’amniocent\u00e8se ou le pr\u00e9l\u00e8vement de villosit\u00e9s choriales, tout en maintenant un niveau \u00e9lev\u00e9 de d\u00e9tection des aneuplo\u00efdies f\u0153tales.<\/p>\n","protected":false},"author":15,"featured_media":2048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-11443","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sante-femme"],"acf":[],"yoast_head":"\nDPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21 - Alpig\u00e8ne<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21 - Alpig\u00e8ne\" \/>\n<meta property=\"og:description\" content=\"Le d\u00e9pistage pr\u00e9natal non invasif (DPNI), , constitue aujourd'hui un examen majeur de d\u00e9pistage de la trisomie 21. Son excellente performance diagnostique permet de r\u00e9duire significativement le recours aux examens invasifs tels que l'amniocent\u00e8se ou le pr\u00e9l\u00e8vement de villosit\u00e9s choriales, tout en maintenant un niveau \u00e9lev\u00e9 de d\u00e9tection des aneuplo\u00efdies f\u0153tales.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/\" \/>\n<meta property=\"og:site_name\" content=\"Alpig\u00e8ne\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-23T16:25:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-24T07:47:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.synlab.fr\/alpigene\/wp-content\/uploads\/sites\/128\/2022\/08\/csm_RS7976_sy_pregnant_woman_at_home_cl_A32487626_clean_2017-scr_9f6c86009f.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"534\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"linsayjeanlouis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"linsayjeanlouis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/\",\"url\":\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/\",\"name\":\"DPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21 - Alpig\u00e8ne\",\"isPartOf\":{\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.synlab.fr\/alpigene\/wp-content\/uploads\/sites\/128\/2022\/08\/csm_RS7976_sy_pregnant_woman_at_home_cl_A32487626_clean_2017-scr_9f6c86009f.jpg\",\"datePublished\":\"2026-07-23T16:25:46+00:00\",\"dateModified\":\"2026-07-24T07:47:10+00:00\",\"author\":{\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/#\/schema\/person\/8df64bd88b7ba216533b24a8fa925919\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#primaryimage\",\"url\":\"https:\/\/www.synlab.fr\/alpigene\/wp-content\/uploads\/sites\/128\/2022\/08\/csm_RS7976_sy_pregnant_woman_at_home_cl_A32487626_clean_2017-scr_9f6c86009f.jpg\",\"contentUrl\":\"https:\/\/www.synlab.fr\/alpigene\/wp-content\/uploads\/sites\/128\/2022\/08\/csm_RS7976_sy_pregnant_woman_at_home_cl_A32487626_clean_2017-scr_9f6c86009f.jpg\",\"width\":800,\"height\":534,\"caption\":\"Femme enceinte allong\u00e9e dans le tapis du salon\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.synlab.fr\/alpigene\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"DPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/#website\",\"url\":\"https:\/\/www.synlab.fr\/alpigene\/\",\"name\":\"Alpig\u00e8ne\",\"description\":\"Un site utilisant Synlab\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.synlab.fr\/alpigene\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/#\/schema\/person\/8df64bd88b7ba216533b24a8fa925919\",\"name\":\"linsayjeanlouis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.synlab.fr\/alpigene\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/fb0f30b8341acdee29fa7b667477549a624e6ad211081851e7f035201a8b288a?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/fb0f30b8341acdee29fa7b667477549a624e6ad211081851e7f035201a8b288a?s=96&d=mm&r=g\",\"caption\":\"linsayjeanlouis\"},\"url\":\"https:\/\/www.synlab.fr\/alpigene\/author\/linsayjeanlouis\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"DPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21 - Alpig\u00e8ne","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"DPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21 - Alpig\u00e8ne","og_description":"Le d\u00e9pistage pr\u00e9natal non invasif (DPNI), , constitue aujourd'hui un examen majeur de d\u00e9pistage de la trisomie 21. Son excellente performance diagnostique permet de r\u00e9duire significativement le recours aux examens invasifs tels que l'amniocent\u00e8se ou le pr\u00e9l\u00e8vement de villosit\u00e9s choriales, tout en maintenant un niveau \u00e9lev\u00e9 de d\u00e9tection des aneuplo\u00efdies f\u0153tales.","og_url":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/","og_site_name":"Alpig\u00e8ne","article_published_time":"2026-07-23T16:25:46+00:00","article_modified_time":"2026-07-24T07:47:10+00:00","og_image":[{"width":800,"height":534,"url":"https:\/\/www.synlab.fr\/alpigene\/wp-content\/uploads\/sites\/128\/2022\/08\/csm_RS7976_sy_pregnant_woman_at_home_cl_A32487626_clean_2017-scr_9f6c86009f.jpg","type":"image\/jpeg"}],"author":"linsayjeanlouis","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"linsayjeanlouis","Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/","url":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/","name":"DPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21 - Alpig\u00e8ne","isPartOf":{"@id":"https:\/\/www.synlab.fr\/alpigene\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#primaryimage"},"image":{"@id":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#primaryimage"},"thumbnailUrl":"https:\/\/www.synlab.fr\/alpigene\/wp-content\/uploads\/sites\/128\/2022\/08\/csm_RS7976_sy_pregnant_woman_at_home_cl_A32487626_clean_2017-scr_9f6c86009f.jpg","datePublished":"2026-07-23T16:25:46+00:00","dateModified":"2026-07-24T07:47:10+00:00","author":{"@id":"https:\/\/www.synlab.fr\/alpigene\/#\/schema\/person\/8df64bd88b7ba216533b24a8fa925919"},"breadcrumb":{"@id":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#primaryimage","url":"https:\/\/www.synlab.fr\/alpigene\/wp-content\/uploads\/sites\/128\/2022\/08\/csm_RS7976_sy_pregnant_woman_at_home_cl_A32487626_clean_2017-scr_9f6c86009f.jpg","contentUrl":"https:\/\/www.synlab.fr\/alpigene\/wp-content\/uploads\/sites\/128\/2022\/08\/csm_RS7976_sy_pregnant_woman_at_home_cl_A32487626_clean_2017-scr_9f6c86009f.jpg","width":800,"height":534,"caption":"Femme enceinte allong\u00e9e dans le tapis du salon"},{"@type":"BreadcrumbList","@id":"https:\/\/www.synlab.fr\/alpigene\/dpni-depistage-pre-natal-non-invasif-de-la-trisomie-foetale\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.synlab.fr\/alpigene\/"},{"@type":"ListItem","position":2,"name":"DPNI : un outil incontournable dans le d\u00e9pistage pr\u00e9natal de la trisomie 21"}]},{"@type":"WebSite","@id":"https:\/\/www.synlab.fr\/alpigene\/#website","url":"https:\/\/www.synlab.fr\/alpigene\/","name":"Alpig\u00e8ne","description":"Un site utilisant Synlab","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.synlab.fr\/alpigene\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/www.synlab.fr\/alpigene\/#\/schema\/person\/8df64bd88b7ba216533b24a8fa925919","name":"linsayjeanlouis","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.synlab.fr\/alpigene\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/fb0f30b8341acdee29fa7b667477549a624e6ad211081851e7f035201a8b288a?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fb0f30b8341acdee29fa7b667477549a624e6ad211081851e7f035201a8b288a?s=96&d=mm&r=g","caption":"linsayjeanlouis"},"url":"https:\/\/www.synlab.fr\/alpigene\/author\/linsayjeanlouis\/"}]}},"_links":{"self":[{"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/posts\/11443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/comments?post=11443"}],"version-history":[{"count":3,"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/posts\/11443\/revisions"}],"predecessor-version":[{"id":11478,"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/posts\/11443\/revisions\/11478"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/media\/2048"}],"wp:attachment":[{"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/media?parent=11443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/categories?post=11443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.synlab.fr\/alpigene\/wp-json\/wp\/v2\/tags?post=11443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}